Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary Target3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase

Cell permeable: yes

General description

Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays.

Carboxylate form of Lovastatin (Cat. No. 438185) that is active in whole cells and cell-free assays. Lovastatin is reported to be an anti-hypercholesterolemic agent that acts as an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase and blocks a series of biological events including activation of p21^ras by insulin in 3T3-L1 fibroblasts and 3T3-L1 adipocytes, farnesylation of p21^ras, which decreases the pool of intracellular Ras available for subsequent activation by growth factors (including insulin), and N-ras-induced neuronal differentiation. Causes cell cycle arrest in the late G₁ phase. Shown to inhibit the stimulation of MAP kinase by insulin in HIRcB cells and block the transcription of the type-I SCR gene in THP-1-derived macrophages. Also blocks PDGF receptor tyrosine phosphorylation and MAP kinase activation by PDGF.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Rao, S., et al. 1999. Proc. Natl. Acad. Sci. USA96, 7197.Carel, K., et al. 1996. J. Biol. Chem.271, 30625.McGuire, T.F., et al. 1996. J. Biol. Chem.271, 27402.Umetani, N., et al. 1996. Biochim. Biophys. Acta1303, 199.Xu, X.Q., et al. 1996. Arch. Biochem. Biophys.326, 233.Reusch, J.E.-B., et al. 1995. J. Biol. Chem.270, 2036.

Packaging

Packaged under inert gas

5 mg in Plastic ampoule

Reconstitution

Following reconstitution, aliquot, flush with an inert gas, and freeze (-20°C). Stock solutions in high quality ethanol are stable for up to 1 month at -20°C.

Warning

Toxicity: Carcinogenic / Teratogenic (D)